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Association between small airway dysfunction and cardiac conditions: a Swiss urban population cross-sectional study

Alessio Casutt^1,2,3, Laurève Chollet^4,5, Cedric Bongard¹

¹Division of Pulmonology, Department of Medicine, Lausanne University Hospital (CHUV), and University of Lausanne (UNIL), Lausanne, Switzerland.

ERJ Open Research

|June 24, 2025

Abstract

Introduction:

Small airway dysfunction (SAD) may be an early sign of cardiopulmonary overload due to small airway mucosal thickening or be related to the oxidative stress characteristic of cardiovascular diseases. A high prevalence of SAD coexisting with chronic heart failure may be associated with an increase in all-cause mortality. We analysed the association between SAD and cardiac conditions in the PneumoLaus study.

Methods:

PneumoLaus is based on the Swiss general urban population cohort CoLaus|PsyCoLaus. SAD was defined by maximal mid-expiratory flow (MMEF) before bronchodilatation <65% predicted or MMEF

Results:

Among 3342 subjects that underwent spirometry, 473 (14.2%) reported a new cardiac condition. SAD defined as MMEF<65% predicted or MMEF

Conclusions:

SAD defined as MMEF

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