Related Experiment Video
Updated: Sep 18, 2025
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
Published on: April 11, 2025
Dissection of 4L lymph node for left-sided non-small cell lung cancer: a meta-analysis
Chenxi Li1,2, Zhuozheng Hu1, Jiajun Wu1
1Department of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Background:
The therapeutic efficacy of left lower paratracheal (4L) lymph node dissection in the management of left-sided non-small cell lung cancer (NSCLC) remains an unresolved clinical question. Therefore, we conducted a meta-analysis to compare the survival of patients with left-sided NSCLC who underwent 4L lymph node dissection (LND+) and those who did not (LND-).
Methods:
Seven databases were searched for relevant studies comparing patients with left-sided NSCLC who underwent 4L lymph node dissection and those who did not. The primary endpoints were survival indicators, including overall survival (OS) and disease-free survival (DFS). Secondary endpoints included hospitalization and follow-up outcomes.
Results:
After thoroughly screening 431 studies, six studies encompassing 4,253 patients were included in the final analysis. The LND+ group showed better OS (hazard ratio [HR]: 0.65 [0.52, 0.81], p < 0.0001) and DFS (HR: 0.82 [0.71, 0.95], p = 0.008). The 4L LND+ group also demonstrated higher OS rates at 1-5 years and DFS at 1 year. Postoperative complications and recurrence rates were similar between the two groups.
Conclusions:
Based on these results, 4L lymph node dissection should be performed for left-sided resectable NSCLC, due to its association with improved OS and DFS.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567681, identifier CRD42024567681.
More Related Videos
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
05:43The Role of Anatomical Dissection in Defining Colic and Small Bowel Artery Lymphovascular Bundles in the D3 Volume of Small and Large Bowel Mesentery
Published on: August 1, 2025