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Updated: Jun 19, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead
Catherine T Haring1, Melina J Windon2, Molly E Heft Neal3
1Department of Otolaryngology - Head and Neck Surgery, The Ohio State University, Columbus, Ohio.
Abstract:
Human papillomavirus (HPV) whole-genome sequencing-based plasma ctDNA analysis has demonstrated high diagnostic accuracy in identifying HPV-positive head and neck cancer, supporting the potential for future clinical validation through biomarker advancement paradigms. In this issue, we discuss how this research opens exciting future directions for liquid biopsy research and clinical implementation for HPV+ head and neck squamous cell carcinoma. See related article by Bryan et al., p. 3483.
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