A Rare Case of HLA-B51 Positive MAGIC Syndrome: A Clinical Conundrum

The term mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome was initially dubbed by Firestein et al. in 1985. He described five patients with clinical manifestations of Behcet's disease (BD) as well as relapsing polychondritis (RP), putting forward the terminology MAGIC syndrome to describe the overlap of the two diseases. Thereafter, not many cases have been documented in the literature. In our case, a 20-year-old male fulfilled the criteria for BD as well as RP and was diagnosed with MAGIC syndrome. Human leukocyte antigen (HLA) typing showed HLA-B51 positivity. He was effectively treated with oral colchicine and oral prednisolone. The patient's symptoms recovered gradually, and prednisolone was tapered and stopped. The exact pathophysiology behind MAGIC syndrome is still unestablished, and the number of cases reported is not sufficient enough to indicate an apparent explanation. Hence, accretion of additional cases and supplementary research is required to enhance the comprehension of MAGIC syndrome.