Confidence-Aware Adaptive Fusion Leaning of Imbalance Multi-Modal Data for Cancer Diagnosis and Prognosis

The effective fusion of pathological images and molecular omics holds significant potential for precision medicine. However, pathological and molecular data are highly heterogeneous, and large-scale multi-modal cancer data often suffer from incomplete information. Predicting clinical tasks from such imbalanced multi-modal data presents a major challenge. Therefore, we propose a confidence-aware adaptive fusion framework CAFusion. The framework adopts a modular design, providing independent and flexible modal feature learning modules to capture high-quality features. To address issues of modal imbalance caused by heterogeneous and incomplete modal, we design a confidence-aware method that evaluates the features of each modal and automatically adjusts their weights. To effectively fuse pathological and molecular modals, we propose an adaptive deep network, which features a flexible, non-fixed layer structure that effectively extracts hidden joint information from multi-modal features, ensuring high generalizability. Experiment results demonstrate that the performance of the CAFusion framework outperforms other state-of-the-art methods, both on complete and incomplete datasets. Moreover, the CAFusion framework offers reasonable medical interpretability.