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Related Concept Videos

Chronic Obstructive Pulmonary Disease-V: Management01:29

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
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Chest Physiotherapy01:24

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Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
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Chronic Obstructive Pulmonary Disease01:22

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Updated: Sep 18, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
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Senotherapy for chronic lung disease.

Peter J Barnes1

  • 1National Heart and Lung Institute, Imperial College, London, United Kingdom.

Pharmacological Reviews
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

Cellular senescence drives chronic lung diseases like COPD and IPF. Senotherapy, using senomorphics and senolytics, shows promise in treating these conditions and is currently in clinical trials.

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Area of Science:

  • Pulmonary Medicine
  • Cellular Biology
  • Gerontology

Background:

  • Chronic respiratory diseases are a leading cause of death globally.
  • Cellular senescence, driven by oxidative stress and DNA damage, accelerates lung aging and disease progression.
  • Reduced levels of antiaging molecules like sirtuins are observed in aging lungs.

Purpose of the Study:

  • To explore cellular senescence as a key mechanism in chronic lung diseases.
  • To review senotherapy as a novel treatment strategy targeting senescent cells.
  • To discuss senomorphic and senolytic drug classes and their therapeutic potential.

Main Methods:

  • Review of evidence linking cellular senescence to chronic lung diseases.
  • Analysis of senotherapy mechanisms, including senomorphics and senolytics.
  • Examination of preclinical and clinical trial data for senotherapies.

Main Results:

  • Cellular senescence and its associated secretory phenotype are implicated in COPD and IPF.
  • Senotherapies, including senomorphics (e.g., mTOR inhibitors, antioxidants, sirtuin activators) and senolytics (e.g., BCL-XL inhibitors, cardiac glycosides), have shown efficacy in animal models.
  • Several senotherapies are progressing through clinical trials for respiratory diseases.

Conclusions:

  • Cellular senescence is a critical driver of chronic lung disease progression.
  • Senotherapy represents a promising therapeutic avenue for treating debilitating respiratory conditions.
  • Further research into long-term safety and efficacy of senotherapies is warranted.