Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

952
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
952

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of the Upper Motor Neuron in the Generation of Fasciculations in Early Disease Stages of Amyotrophic Lateral Sclerosis.

Neurology·2026
Same author

Enhanced spinal motoneuron excitability as a marker of motor neuron dysfunction in primary lateral sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Environmental Personal Exposure Clusters to Investigate Multiple Sclerosis and Amyotrophic Lateral Sclerosis Progression.

Studies in health technology and informatics·2026
Same author

Interleukin-6 in ALS: metabolic mediator or marker of ventilatory decline?

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

The Cat is Out of the Bag: Confronting False-Positive Risks in Amyotrophic Lateral Sclerosis Clinical Trials.

Neurology·2026
Same author

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Nature genetics·2026
Same journal

Surface EEG to Identify Cognitive Motor Dissociation After Acute Brain Injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

The Physics and Physiology of Electrical Stimulation of the Brain.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Neurophysiology in Postanoxic Encephalopathy: Pathophysiology, Prognosis, and Treatment.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

A Review on the Functional Connectivity of the Human Opercular Cortex.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Surgical Aspects of Opercular Epilepsies.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Cost-Effectiveness of EEG Monitoring in Hypoxic-Ischemic Brain Injury After Cardiac Arrest.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

526

Nerve Conduction Studies of Phrenic Nerve: Normative Data.

José Castro1,2, Mamede de Carvalho1,2

  • 1Instituto de Fisiologia, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal ; and.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

Nerve conduction studies of the phrenic nerve (PN) are a reliable method to assess diaphragm function in neuromuscular diseases. Results show that sex and age significantly influence diaphragm motor responses, with higher amplitudes on the left side.

Keywords:
AgeAmyotrophic lateral sclerosisMotor conductionNormative valuesPhrenic nerve

More Related Videos

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.2K
In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
11:07

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

Published on: April 13, 2014

34.0K

Related Experiment Videos

Last Updated: Sep 18, 2025

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

526
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.2K
In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
11:07

In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

Published on: April 13, 2014

34.0K

Area of Science:

  • Neurology
  • Respiratory Medicine
  • Clinical Electrophysiology

Background:

  • Respiratory failure is a significant complication in neuromuscular diseases.
  • Pulmonary function tests are standard but can be affected by various factors.
  • Phrenic nerve (PN) conduction studies offer a noninvasive method to evaluate diaphragm compromise.

Purpose of the Study:

  • To assess diaphragm motor responses via PN conduction studies.
  • To determine the influence of anthropometric variables (sex, age, height, weight) on diaphragm motor responses.
  • To analyze side-to-side differences in PN compound muscle action potential (CMAP).

Main Methods:

  • Studied 132 healthy subjects (78 males, aged 23-90 years).
  • Performed bilateral PN stimulation and recorded diaphragm motor responses.
  • Collected anthropometric data and analyzed its effect on CMAP and side-to-side variations.

Main Results:

  • Left PN CMAP amplitude and area were significantly higher than the right.
  • Men exhibited longer latency and higher amplitude/area compared to women.
  • Age significantly impacted CMAP latency (0.25 ms increase per decade). Established normative values for men and women.

Conclusions:

  • PN conduction studies are a simple, reliable, and clinically applicable technique.
  • Diaphragm CMAP parameters are significantly influenced by sex and age.
  • Left-sided PN demonstrates greater CMAP amplitude and area.