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Heart failure treatment patterns: A pharmacoepidemiological descriptive study in Colombia (The HEATCO study)
Manuel E Machado-Duque1,2, Andrés Gaviria-Mendoza1,2, Luis F Valladales-Restrepo1,2
1Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia. Universidad Tecnológica de Pereira - Audifarma S.A. Pereira, Colombia.
Plos One
|June 24, 2025
Summary
Heart failure medication patterns in Colombia show high use of beta-blockers and RAAS inhibitors. However, guideline-adherent therapies are less common for patients with reduced ejection fraction (LVEF).
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Heart failure (HF) is a prevalent condition with high mortality rates.
- Understanding medication prescription patterns is crucial for optimizing HF management.
- This study focuses on HF patient treatment in Colombia.
Purpose of the Study:
- To analyze medication prescription patterns for heart failure patients in Colombia.
- To identify factors influencing treatment choices.
- To compare adherence to guidelines based on left ventricular ejection fraction (LVEF).
Main Methods:
- Retrospective analysis of clinical records from 2019-2020.
- Inclusion of 4742 heart failure patients.
- Data collected on sociodemographics, clinical status, and prescribed medications, including LVEF.
Main Results:
- High prescription rates for beta-blockers (88.3%) and RAAS inhibitors (83.1%).
- Triple therapy (RAASi + beta-blocker + MRA) used in 56.4% of reduced LVEF patients.
- Quadruple therapy with SGLT2 inhibitors was low (4.6% in reduced LVEF).
Conclusions:
- Treatment for preserved LVEF aligns better with guidelines.
- Adherence to recommended therapies is lower for patients with reduced LVEF.
- Opportunities exist to improve guideline-directed medical therapy in Colombian HF patients.
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