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Updated: Sep 18, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

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Heart failure treatment patterns: A pharmacoepidemiological descriptive study in Colombia (The HEATCO study)

Manuel E Machado-Duque1,2, Andrés Gaviria-Mendoza1,2, Luis F Valladales-Restrepo1,2

  • 1Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia. Universidad Tecnológica de Pereira - Audifarma S.A. Pereira, Colombia.

Plos One
|June 24, 2025
PubMed

Insights

Heart failure medication patterns in Colombia show high use of beta-blockers and RAAS inhibitors. However, guideline-adherent therapies are less common for patients with reduced ejection fraction (LVEF).

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Heart failure (HF) is a prevalent condition with high mortality rates.
  • Understanding medication prescription patterns is crucial for optimizing HF management.
  • This study focuses on HF patient treatment in Colombia.

Purpose of the Study:

  • To analyze medication prescription patterns for heart failure patients in Colombia.
  • To identify factors influencing treatment choices.
  • To compare adherence to guidelines based on left ventricular ejection fraction (LVEF).

Main Methods:

  • Retrospective analysis of clinical records from 2019-2020.
  • Inclusion of 4742 heart failure patients.
  • Data collected on sociodemographics, clinical status, and prescribed medications, including LVEF.

Main Results:

  • High prescription rates for beta-blockers (88.3%) and RAAS inhibitors (83.1%).
  • Triple therapy (RAASi + beta-blocker + MRA) used in 56.4% of reduced LVEF patients.
  • Quadruple therapy with SGLT2 inhibitors was low (4.6% in reduced LVEF).

Conclusions:

  • Treatment for preserved LVEF aligns better with guidelines.
  • Adherence to recommended therapies is lower for patients with reduced LVEF.
  • Opportunities exist to improve guideline-directed medical therapy in Colombian HF patients.
Abstract

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