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Significant Role for Maternal Genetic Nurture in the Risk Architecture of Attention Deficit Hyperactivity Disorder

Behrang Mahjani1, Adrianna P Kępińska1, Shelby Smout1

  • 1Seaver Autism Center for Research and Treatment (Mahjani, Kępińska, Smout, Cohen, Caballero, Buxbaum, Grice), Department of Psychiatry (Mahjani, Kępińska, Smout, Cohen, Caballero, Buxbaum, Grice), Department of Genetics and Genomic Sciences (Mahjani, Kępińska, Buxbaum), Department of Artificial Intelligence and Human Health (Mahjani), Mindich Child Health and Development Institute (Mahjani, Buxbaum, Grice), Friedman Brain Institute (Buxbaum), Department of Neuroscience (Buxbaum), and Division of Tics, OCD, and Related Disorders (Grice), Icahn School of Medicine at Mount Sinai, New York; Department of Molecular Medicine and Surgery and Department of Medical Epidemiology and Biostatistics (Mahjani), Karolinska Institutet, Stockholm.

The American Journal of Psychiatry
|June 25, 2025
PubMed
Summary

Maternal genetic nurture significantly impacts offspring attention deficit hyperactivity disorder (ADHD) risk, beyond direct genetic inheritance. This highlights the importance of maternal environmental influences on ADHD development.

Keywords:
Attention Deficit Hyperactivity Disorder (ADHD)Genetics/GenomicsNeurodevelopmental Disorders

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