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Updated: Sep 18, 2025

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Published on: April 22, 2016
Visible Light-Mediated Spiroannulation of o-Alkynyl Acrylamides Using Excited-State Palladium Catalysis
Kirti Khanna1, Ganesh Chandra Upreti1, Parashuram Sharma1
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Abstract:
A photoinduced, Pd-catalyzed spiroannulation of 1,7-enynes has been developed. This reaction employs simple alkyl halides as radical precursors to initiate a radical addition/cyclization cascade of o-alkynyl acrylamides, resulting in spiroannulated tetracyclic systems. Using a widely available and simple palladium catalyst, this protocol demonstrates good scope and functional group tolerance under mild reaction conditions and provides expedient access to complex spirocyclic molecular architectures.
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