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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Extraction: Advanced Methods00:56

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Insight into charged drug release from metal-organic frameworks.

Josh Phipps1, Luis Pinzon-Hererra2, Wenlu Fan1

  • 1Department of Chemistry, University of North Texas, Denton, Texas 76205, USA. shengqian.ma@unt.edu.

Nanoscale
|June 25, 2025
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Summary
This summary is machine-generated.

Metal-organic frameworks (MOFs) show promise for drug delivery, but understanding release mechanisms is key. This study explores how MOF properties and solution conditions affect charged molecule release, developing a new model for biphasic release profiles.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Metal-organic frameworks (MOFs) are promising for biological applications, yet their use in drug delivery is limited by a lack of understanding regarding release kinetics.
  • Factors like MOF composition and solution conditions significantly influence the loading and release of charged molecules.

Purpose of the Study:

  • To investigate how functional groups on MOFs and surrounding electrostatic interactions affect the release of charged drug models.
  • To develop an improved model for describing biphasic drug release profiles from MOFs.

Main Methods:

  • Synthesis of various MOFs (MIL-100, UiO-66, UiO-66-NH2, UiO-66-NO2, UiO-66-OH).
  • Evaluation of charged dye and drug model loading and release influenced by buffer molecules, ions, and polyelectrolytes.
  • Application and novel adaptation of the Korsmeyer-Peppas (K-P) model to analyze release mechanisms, including biphasic profiles.

Main Results:

  • The study identified key interactions influencing the release of charged molecules from different MOF structures.
  • The conventional K-P model was insufficient for describing observed biphasic release patterns.
  • A novel adapted K-P model successfully described biphasic release, revealing previously unobserved phenomena.

Conclusions:

  • Understanding the influence of MOF functional groups and solution conditions is crucial for optimizing drug delivery.
  • The adapted K-P model provides a more accurate description of complex drug release kinetics from MOFs.
  • These findings can be leveraged to enhance the controlled release of charged drugs using MOF platforms.