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Real World Side-Effects of Dupilumab: A Narrative Review
Conor Larney1,2, Peter Foley1,2,3, Jason Wu4
1Department of Dermatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
The Australasian Journal of Dermatology
|June 25, 2025
Summary
Real-world dupilumab use shows side effects beyond clinical trials. Awareness of these adverse events, including ocular, skin, and inflammatory issues, is crucial for effective atopic dermatitis management.
Area of Science:
- Dermatology
- Immunology
- Clinical Medicine
Background:
- Dupilumab is an effective biologic for atopic dermatitis.
- Initial clinical trials did not fully capture the spectrum of real-world side effects.
Purpose of the Study:
- To document and highlight adverse events associated with real-world dupilumab use.
- To inform clinicians about potential side effects not fully identified in prior studies.
Main Methods:
- Review of real-world data on dupilumab utilization.
- Analysis of reported adverse events and associated conditions.
Main Results:
- Dupilumab use is associated with various side effects.
- Observed adverse events include ocular complications, inflammatory arthritis, psoriasiform eruptions, and head and neck dermatitis.
- Reported associations also include cutaneous T-cell lymphoma, alopecia areata, vitiligo, and weight gain.
Conclusions:
- Clinicians must be vigilant for a broader range of side effects with dupilumab.
- Real-world data expands the understanding of dupilumab's safety profile beyond clinical trial findings.
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