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Targeted Systemic Therapies for Atopic Dermatitis in Australia: A Narrative Review.

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  • 1Woden Dermatology, Canberra, ACT, Australia.

The Australasian Journal of Dermatology
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PubMed
Summary

Patients with moderate-to-severe atopic dermatitis (AD) in Australia lack access to guideline-recommended systemic therapies. Improving health technology assessments is crucial for equitable access to these effective treatments.

Keywords:
Australiaatopic dermatitishealth technology assessmentreimbursementsystemic

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Area of Science:

  • Dermatology
  • Health Economics
  • Health Policy

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition.
  • Moderate-to-severe AD affects a significant portion of the Australian population.
  • Current topical treatments are insufficient for many patients with moderate-to-severe AD.

Purpose of the Study:

  • To review health technology assessment (HTA) processes and systemic therapy access for moderate-to-severe AD in Australia.
  • To compare Australia's access to guideline-recommended therapies with countries like the UK, Canada, New Zealand, and France.
  • To identify barriers to funded/subsidised access for targeted systemic agents in Australia.

Main Methods:

  • Narrative review of HTA processes.
  • Analysis of funded/subsidised targeted systemic therapy availability for moderate-to-severe AD (patients aged ≥12 years).
  • Comparison across Australia and comparable international healthcare systems.

Main Results:

  • Australia has limited access to globally launched medicines for moderate-to-severe AD.
  • International availability of guideline-recommended targeted systemic agents varies due to approval and reimbursement differences.
  • Healthcare providers face limitations in treating moderate-to-severe AD without access to these medications.

Conclusions:

  • Australian patients require funded or subsidised access to effective, well-tolerated systemic medications for moderate-to-severe AD.
  • Current HTA procedures may not adequately address the environment of high-cost targeted therapeutics.
  • Updating HTA processes is recommended to improve patient access to essential treatments.