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New Therapeutic Options for Fusariosis: A Patent Review (2008-2023)

Izadora Dillis Faccin1, Túlio Máximo Salomé1, Gleyce Hellen de Almeida de Souza1

  • 1Health Sciences Research Laboratory, Universidade Federal of Grande Dourados, 79804-970 Dourados, Brazil.

Journal of Fungi (Basel, Switzerland)
|June 25, 2025
PubMed

Insights

Antifungal resistance necessitates new treatments for Fusariosis. Patent analysis reveals innovation in drug delivery, gene expression, and novel compounds for human Fusarium infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmaceutical Sciences

Background:

  • Fusariosis, caused by *Fusarium* species, affects plants and humans.
  • Current treatments (azoles, polyenes) face rising antifungal resistance.
  • Novel therapeutic strategies are crucial for managing Fusariosis.

Purpose of the Study:

  • To review patents for Fusariosis treatments over the last 15 years (up to June 2023).
  • To identify trends in therapeutic approaches and mechanisms of action.
  • To assess the landscape of innovation in combating *Fusarium* infections.

Main Methods:

  • Systematic patent search using International Patent Classification and Cooperative Patent Classification.
  • Bibliographic search in PubMed for scientific articles.
  • Categorization of patents by identification code, publication date, application type, and mechanism.

Main Results:

  • 318 patents related to Fusariosis treatment were identified.
  • 21 patents specifically targeted human Fusarium infections.
  • Key innovation areas include drug delivery, gene expression, immunotherapy, engineered drugs, and novel compounds.
  • Peak patent activity observed in 2014 and 2018.

Conclusions:

  • The patent landscape indicates active research into new Fusariosis therapies.
  • Diverse mechanisms, including advanced drug delivery and immunotherapy, are being explored.
  • Continued innovation is essential to address the challenge of antifungal resistance in Fusariosis treatment.
Keywords:
Fusariumantifungal agentsdrug innovationfungal infection

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