Principles for Novel Neurologic Therapeutics: An AAN Position Statement

Area of Science:

• Neurology
• Health Policy
• Evidence-Based Medicine

Background:

• The American Academy of Neurology (AAN) provides guidance on therapies with potential neurologic benefits but limited evidence or no FDA approval.
• This includes situations where patients consider accessing treatments under

Purpose of the Study:

• To outline the AAN's principles for advising policymakers on therapies with limited scientific validation.
• To guide neurologists and patients in evaluating novel treatments with uncertain efficacy and safety profiles.

Main Methods:

• This is a policy statement outlining general principles.
• It involves expert consensus and review of existing evidence frameworks.

Main Results:

• The AAN recommends a collaborative approach between neurologists and patients.
• This involves a thorough review of available data and a discussion of potential risks and benefits.

Conclusions:

• Careful consideration and informed discussion are crucial when evaluating therapies with limited evidence.
• The AAN emphasizes patient-centered decision-making in complex therapeutic scenarios, including "right to try" considerations.