A rare case of a primary atrial myxoma with metaplastic ossification and its multimodal imaging features

Cardiac myxomas are rare, benign intracardiac tumors that arise from pluripotent mesenchymal stem cells. The vast majority of myxomas consist of mesenchymal stem cells suspended within a mucoid, gelatinous material.

A 55-year-old woman presented with progressive chest pain due to a left atrial myxoma with unusual calcification. A complete resection was performed and pathology confirmed the diagnosis of myxoma with metaplastic ossification.

This case represents the diagnostic challenges of atypical myxomas and emphasizes the importance of multimodal anatomic and functional imaging for accurate preoperative assessment.

This case showcases the heterogeneity of cardiac myxomas, the typical natural history, and the value of multimodal imaging in managing these rare intracardiac tumors.