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Updated: Sep 18, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Antisense oligonucleotides as drugs with both direct and indirect antiviral actions
1Aligos Therapeutics Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA, 94080, USA.
Abstract:
In this review, we provide a historical and current guide of recent advances in the development of ASOs either targeting viruses directly, or indirectly through modulation of host factors. Although preclinical and discovery assets are mentioned in this review, more extensive coverage is given to clinical stage assets. Most of these clinical assets are currently concentrated in the fight to eradicate hepatitis B virus (HBV), and hepatitis C virus (HCV). Progresses have also been made in extrahepatic delivery of oligonucleotides and the possibility of treating respiratory virus infections in lungs with ASOs would be feasible.
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