Related Experiment Video
Updated: Sep 18, 2025
A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC
Published on: March 15, 2017
Five undescribed ent-labdane diterpenoid glucosides from Andrographis paniculata and their anti-inflammatory activity
Xiao Zhang1, Ya-Ting Lai1, Yu-Chun Chen1
1State Key Laboratory of Traditional Chinese Medicine Syndrome, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Abstract:
A phytochemical investigation on the leaves of medicinal plant Andrographis paniculata resulted in the isolation of five previously undescribed ent-labdane diterpenoid glucosides (1-5), along with ten known ones (6-15). Their chemical structures with absolute configurations were thoroughly elucidated on the basis of comprehensive spectroscopic analysis, single-crystal X-ray crystallographic experiment and acid hydrolysis. All the isolated compounds were measured for the production of nitric oxide levels in LPS-induced RAW 264.7 macrophages to assess their anti-inflammatory activity. Compounds 4, 6, 10-12 and 14 showed potential anti-inflammatory activity.
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...