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A new device for delayed hypersensitivity skin testing.

G Carle, J L Duncan, S Thomson

    Journal of the American College of Nutrition
    |January 1, 1985
    PubMed
    Summary
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    A new Multitest CMI device for assessing delayed cutaneous hypersensitivity identified more anergic patients than conventional testing. This suggests Multitest CMI better identifies patients at higher risk for complications.

    Area of Science:

    • Immunology
    • Clinical Medicine
    • Nutritional Support

    Background:

    • Delayed cutaneous hypersensitivity (DCH) is a key immune function.
    • Assessing DCH is crucial for identifying immunocompromised patients.
    • Nutritional support patients often require immune status evaluation.

    Purpose of the Study:

    • To compare the efficacy of Multitest CMI with conventional intradermal testing for DCH assessment.
    • To determine if Multitest CMI improves the identification of clinically significant anergy in patients needing nutritional support.

    Main Methods:

    • A cohort of 83 patients referred for nutritional support was studied.
    • Delayed cutaneous hypersensitivity was assessed using Multitest CMI (seven antigens) and conventional intradermal recall antigens.

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  • Patient outcomes, including complications, were recorded.

    • Main Results:

    • Anergia was detected in 19.3% of patients using Multitest CMI versus 4.8% with conventional testing.
    • Patients identified as anergic by Multitest CMI exhibited a higher incidence of complications (e.g., intraabdominal abscess, sepsis).

    Conclusions:

    • Multitest CMI demonstrates higher specificity than conventional testing in identifying clinically important anergy.
    • The Multitest CMI device is a valuable tool for risk stratification in patients requiring nutritional support.