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Updated: Sep 18, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and
Malte Maria Sieren1,2, Hanna Grasshoff3, Gabriela Riemekasten3
1Institute of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Luebeck, Germany malte.sieren@uksh.de.
Introduction:
Systemic sclerosis (SSc) is a complex inflammatory vasculopathy with diverse symptoms and variable disease progression. Despite its known impact on body composition (BC), clinical decision-making has yet to incorporate these biomarkers. This study aims to extract quantitative BC imaging biomarkers from CT scans to assess disease severity, define BC phenotypes, track changes over time and predict survival.
Materials And Methods:
CT exams were extracted from a prospectively maintained cohort of 452 SSc patients. 128 patients with at least one CT exam were included. An artificial intelligence-based 3D body composition analysis (BCA) algorithm assessed muscle volume, different adipose tissue compartments, and bone mineral density. These parameters were analysed with regard to various clinical, laboratory, functional parameters and survival. Phenotypes were identified performing K-means cluster analysis. Longitudinal evaluation of BCA changes employed regression analyses.
Results:
A regression model using BCA parameters outperformed models based on Body Mass Index and clinical parameters in predicting survival (area under the curve (AUC)=0.75). Longitudinal development of the cardiac marker enabled prediction of survival with an AUC=0.82. Patients with altered BCA parameters had increased ORs for various complications, including interstitial lung disease (p<0.05). Two distinct BCA phenotypes were identified, showing significant differences in gastrointestinal disease manifestations (p<0.01).
Conclusion:
This study highlights several parameters with the potential to reshape clinical pathways for SSc patients. Quantitative BCA biomarkers offer a means to predict survival and individual disease manifestations, in part outperforming established parameters. These insights open new avenues for research into the mechanisms driving body composition changes in SSc and for developing enhanced disease management tools, ultimately leading to more personalised and effective patient care.
