Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study

Topical application of molecular hydrogen (H₂) has recently emerged as a promising strategy to counteract oxidative stress-related skin damage. This pilot clinical study aimed to assess the efficacy of hydrogen-rich water treatments in improving objective skin parameters in healthy adults. The hypothesis was that H₂, through its selective antioxidant and anti-inflammatory properties, would reduce oxidative stress, modulate inflammatory pathways, and enhance skin barrier integrity, leading to measurable improvements in skin appearance. Fifteen participants received topical treatments with hydrogen-rich water for four weeks. Skin parameters, including porphyrin levels, pigmentation irregularities, pore size, wrinkle severity, and biological skin age, were quantitatively assessed before and one week post-treatment. A statistically significant reduction in pore visibility was observed, particularly in younger participants. Although porphyrin levels showed a trend toward reduction, this change was not statistically significant. Improvements were also noted in pigmentation, wrinkle severity, and estimated biological skin age. The treatment was well tolerated, with no adverse effects reported. Despite promising outcomes, this study was limited by the absence of a control group and a relatively short follow-up period. Further controlled studies with larger sample sizes and molecular biomarker analyses are needed to confirm these effects and elucidate the underlying mechanisms. This study addresses a gap in the literature regarding standardized, clinical evaluation of topical H₂ application and highlights its potential for utilization in cosmetic and preventive dermatology.