Related Experiment Video

Updated: Sep 18, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

871

The Future of Chronic Kidney Disease Treatment: Combination Therapy (Polypill) or Biomarker-Guided Personalized

Sajjad Biglari1,2, Harald Mischak1, Joachim Beige3,4

  • 1Mosaiques Diagnostics GmbH, 30659 Hannover, Germany.

Biomolecules
|June 26, 2025
PubMed

Insights

This review explores recent advances in chronic kidney disease (CKD) pharmacotherapy, focusing on drug combinations and personalized treatments using biomarkers for better patient outcomes.

Area of Science:

  • Nephrology
  • Pharmacology
  • Biomarkers

Background:

  • Chronic kidney disease (CKD) is a significant global health issue with rising incidence and costs.
  • Current healthcare systems face challenges in managing the growing CKD patient population.

Purpose of the Study:

  • To provide an in-depth assessment of advances in CKD pharmacotherapy from 2020-2025.
  • To emphasize the role of drug combinations and biomarker-guided therapy in personalized CKD management.

Main Methods:

  • Systematic literature search for studies published between 2020 and 2025.
  • Narrative review synthesizing findings on CKD pharmacotherapy, drug combinations, and predictive biomarkers.

Main Results:

  • Drug combinations offer potential for improved CKD outcomes but carry risks of adverse effects and costs.
  • Biomarker-based approaches enable personalized CKD treatment tailored to individual molecular profiles.
  • Current methods for guiding CKD therapy based on treatment response markers are presented.

Conclusions:

  • Personalized medicine, utilizing biomarkers, holds promise for optimizing CKD treatment strategies.
  • Combining pharmacotherapies and biomarker-guided approaches may lead to more effective CKD management.
  • Further research into tailored therapies can improve patient outcomes and reduce healthcare burdens.

Keywords:
biomarker-guided therapychronic kidney diseasecombination therapypersonalized medicinetherapeutic interventionstreatment response prediction

More Related Videos

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells10:23

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

3.2K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.5K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
84
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
76
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
61
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
51
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
107