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Ventricular Arrhythmias and Myocardial Infarction: Electrophysiological and Neuroimmune Mechanisms

Meng Zheng1,2,3, Zhen Zhou1,2,3, Ke-Qiong Deng1,2,3

  • 1Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China.

Biomedicines
|June 26, 2025
PubMed

Insights

Ventricular arrhythmias after myocardial infarction remain a major cause of death. New research explores the neuroimmune and electrophysiological mechanisms, offering novel therapeutic targets for these dangerous heart rhythm disturbances.

Area of Science:

  • Cardiology
  • Neuroimmunology
  • Electrophysiology

Background:

  • Ventricular arrhythmias (VAs) post-myocardial infarction (MI) are a leading cause of cardiovascular mortality despite current treatments.
  • Understanding the underlying mechanisms of VAs after MI is crucial for developing improved therapeutic strategies.

Purpose of the Study:

  • To review the electrophysiological and neuroimmune mechanisms contributing to VAs following MI.
  • To highlight the interplay between the sympathetic nervous system, immune cells, and cardiovascular health.

Main Methods:

  • Literature review focusing on neuroimmune pathways and electrophysiological changes in post-MI VAs.
  • Analysis of the bidirectional communication between the sympathetic nervous system and immune responses.
  • Examination of the influence of lifestyle factors (sleep, exercise) on neuroimmune cardiovascular regulation.

Main Results:

  • The sympathetic nervous system (SNS) regulates immune cells via neuroendocrine molecules.
  • Immune cells modulate the SNS through cytokine and chemokine release.
  • Factors like sleep, health, and exercise impact cardiovascular health via neuroimmune pathways.

Conclusions:

  • The neuroimmune axis plays a significant role in the development and persistence of VAs after MI.
  • Interdisciplinary approaches combining electrophysiology and neuroimmunology are essential for novel therapeutic discoveries.
  • Targeting neuroimmune interactions presents a promising avenue for managing post-MI VAs.

Keywords:
crosstalkimmune systemmyocardial infarctionsympathetic nervous systemventricular arrhythmias

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