Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

14.6K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
14.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Wound Healing: A Mystery Still to Be Solved-What Is the Future?

Biomedicines·2026
Same author

An Update on the Correlation Between Neuroimmunomodulation, Photodynamic Therapy (PDT), and Wound Healing: The Role of Mast Cells.

Biomedicines·2026
Same author

Laser Emission at 675 nm: Molecular Counteraction of the Aging Process.

Biomedicines·2025
Same author

Molecular Biomarkers in Cutaneous Photodynamic Therapy: A Comprehensive Review.

Diagnostics (Basel, Switzerland)·2024
Same author

Photodynamic Therapy 2.0.

Biomedicines·2024
Same author

Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Sep 18, 2025

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

8.9K

Editorial: Photodynamic Therapy (3rd Edition).

Stefano Bacci1

  • 1Research Unit of Histology and Embryology, Department of Biology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

Biomedicines
|June 26, 2025
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT), a treatment using light, a photosensitizer, and oxygen, has a history dating back to 1903. This approach remains a significant area of medical research and application.

More Related Videos

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.2K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.6K

Related Experiment Videos

Last Updated: Sep 18, 2025

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

8.9K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.2K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.6K

Area of Science:

  • Biomedical Engineering
  • Photochemistry
  • Medical Physics

Background:

  • Photodynamic therapy (PDT) leverages the interaction of light, a photosensitizing agent, and molecular oxygen to generate reactive oxygen species.
  • The foundational principles of PDT were established in the early 20th century, with significant advancements in recent decades.
  • PDT is recognized for its targeted therapeutic effects and minimal invasiveness.

Discussion:

  • The efficacy of PDT is dependent on factors such as photosensitizer properties, light delivery, and tumor microenvironment.
  • Ongoing research explores novel photosensitizers and light sources to enhance PDT effectiveness and expand its clinical applications.
  • Optimizing treatment parameters is crucial for maximizing therapeutic outcomes and minimizing side effects.

Key Insights:

  • PDT offers a mechanism for selective cell destruction through photogenerated reactive oxygen species.
  • The historical development of PDT highlights a progression from basic principles to sophisticated clinical applications.
  • Understanding the photophysical and photochemical processes is key to advancing PDT.

Outlook:

  • Future directions include the development of theranostic PDT agents for combined diagnosis and therapy.
  • Integration of PDT with other treatment modalities, such as immunotherapy, shows promise for synergistic effects.
  • Personalized PDT approaches, tailored to individual patient and disease characteristics, are anticipated.