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The Wound Healing: A Mystery Still to Be Solved-What Is the Future?

Montserrat Fernández-Guarino1, María Luisa Hernández Bule2, Stefano Bacci1,3

  • 1Dermatology Service, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), 28034 Madrid, Spain.

Biomedicines
|May 4, 2026
PubMed

Insights

This review summarizes recent advances in wound healing mechanisms, highlighting challenges in understanding pathological conditions like diabetic wounds and keloids. Novel therapeutic strategies are also discussed for improved patient outcomes.

Area of Science:

  • Cellular and Molecular Biology
  • Dermatology
  • Regenerative Medicine

Background:

  • Wound healing is a complex biological process involving coordinated cellular and molecular events.
  • Current understanding of these pathways is incomplete, leading to challenges in treating various wound pathologies.
  • Pathological conditions include keloids, hypertrophic scars, chronic wounds, and diabetic wounds.

Purpose of the Study:

  • To provide a current perspective on cellular and molecular mechanisms in wound healing.
  • To highlight inadequacies in characterizing biological pathways involved in wound repair.
  • To discuss novel therapeutic approaches for pathological wound conditions.

Main Methods:

  • Review of scientific literature from 2023-2025.
  • Analysis of cellular and molecular mechanisms.
  • Identification of therapeutic strategies.

Main Results:

  • Wound healing mechanisms are complex and not fully understood.
  • Inadequate characterization contributes to pathological conditions.
  • Emerging therapies show promise for treating difficult wounds.

Conclusions:

  • Further research is needed to fully elucidate wound healing pathways.
  • Improved understanding is critical for managing pathological wound conditions.
  • Novel therapies offer potential for enhanced wound management and patient care.
Keywords:
acute woundscellular infiltratechronic woundskeloidsscars

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