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Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss.

Junchao Zeng1, Jing Li2,3,4, Bo Liu5

  • 1Medical Ultrasound Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Advanced Bio-Medical Imaging Facility, Huazhong University of Science and Technology, Wuhan 430074, China.

Bioengineering (Basel, Switzerland)
|June 26, 2025
PubMed
Summary

Sudden sensorineural hearing loss (SSHL) disrupts brain connectivity. Dynamic analysis reveals brain plasticity, with altered regional homogeneity linked to tinnitus and hearing loss duration.

Keywords:
dynamic local metriclocal brain connectivityneuroimaging biomarkersunilateral sudden sensorineural hearing loss

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Area of Science:

  • Neuroscience
  • Audiology
  • Medical Imaging

Background:

  • Unilateral sudden sensorineural hearing loss (SSHL) has an abrupt onset and poorly understood causes.
  • It presents significant clinical challenges due to its sudden nature and complex etiology.

Purpose of the Study:

  • To investigate static and dynamic changes in local brain connectivity in SSHL patients.
  • To explore the relationship between neural alterations and clinical symptoms of SSHL.

Main Methods:

  • Regional homogeneity (ReHo) analyses were performed on 102 SSHL patients and 73 healthy controls.
  • Both static and dynamic ReHo analyses were utilized to assess brain connectivity.
  • Correlation analyses examined links between ReHo metrics and clinical parameters like tinnitus and hearing loss duration.

Main Results:

  • SSHL patients showed disrupted local synchronization in motor and cognitive brain regions compared to controls.
  • Dynamic ReHo analysis indicated increased temporal variability in frontal regions, suggesting neural plasticity.
  • Significant correlations were found between static ReHo in the left precentral gyrus and tinnitus severity, and dynamic ReHo in the middle frontal gyrus and hearing loss duration.

Conclusions:

  • SSHL involves a complex interplay of static neural dysregulation and dynamic adaptive mechanisms.
  • Dynamic brain connectivity metrics offer a novel perspective on neural reorganization following acute sensory loss.
  • Findings highlight the brain's adaptive capacity and potential therapeutic targets in SSHL.