Role of Combined Use of Adiponectin and hsCRP in Cardiovascular Risk in Pediatric Neurogenic Bladder
Joanna Bagińska-Chyży1, Alicja Szymańska1, Agata Korzeniecka-Kozerska1
1Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngton Str., 15-274 Białystok, Poland.
Insights
Children with neurogenic bladder (NB) show elevated high-sensitivity C-reactive protein (hsCRP), indicating increased cardiovascular disease (CVD) risk. Adiponectin levels are also altered, suggesting complex metabolic links to CVD in this population.
Area of Science:
- Pediatric Cardiology
- Neurology
- Biochemistry
Background:
- Myelomeningocele (MMC) is a severe spina bifida form leading to lower limb paralysis and neurogenic bladder (NB).
- These conditions can predispose to nutritional disorders and future cardiovascular diseases (CVDs).
- High-sensitivity C-reactive protein (hsCRP) is a CVD marker, while adiponectin has anti-inflammatory properties.
Purpose of the Study:
- To evaluate cardiovascular disease risk in children with neurogenic bladder.
- To compare serum levels of adiponectin, hsCRP, and lipid profiles between children with NB and a control group.
Main Methods:
- Prospective clinical study of 87 children (67 NB, 20 controls).
- Collected data: sex, age, anthropometrics (BMI), spinal lesion level, activity (Hoffer's scale).
- Assessed lipid profiles, hsCRP, and adiponectin via standard tests and ELISA kits.
Main Results:
- Statistically significant differences in adiponectin and hsCRP levels between NB and control groups.
- Positive correlation between hsCRP and BMI; negative correlation between adiponectin and BMI.
- Highest hsCRP concentrations observed in MMC patients with thoracic lesions and non-walkers.
Conclusions:
- Elevated hsCRP suggests increased cardiovascular risk in children with neurogenic bladder.
- Altered adiponectin levels indicate a complex association with cardiovascular risk, potentially involving additional metabolic pathways.
Abstract:
Background/Objectives: Myelomeningocele (MMC) is the most severe form of spina bifida, often accompanied by impaired motor function due to paralysis of the lower limbs, as well as neurogenic bladder (NB). These factors may contribute to nutritional disorders and cardiovascular diseases (CVDs) in the future. High-sensitivity CRP (hsCRP) is a positive marker of unstable atherosclerotic plaques and is commonly used in the diagnosis of CVDs. Adiponectin has an opposite, anti-inflammatory function. The aim of this study was to assess the risk of CVDs in a group of children with NB and a control group, based on serum levels of adiponectin, hsCRP, and lipid profiles. Methods: A prospective clinical estimation based on 87 children (67 NB, 20 control group) was conducted. Data collected from medical histories included the following: sex, age, anthropometric parameters (height, weight, BMI), level of spinal lesion, and activity according to Hoffer's scale. Lipid profile values (cholesterol, HDL, LDL, triglycerides) were assessed using standard blood sample tests. hsCRP and adiponectin were measured using an ELISA kit. Results: A comparison of adiponectin and hsCRP levels revealed statistically significant differences between the NB group and the control. Additionally, significant correlations were identified between BMI and the biomarkers: hsCRP was positively associated with BMI, whereas adiponectin exhibited a negative association. The highest concentrations of hsCRP were detected in MMC patients with a Th lesion level and in non-walker patients. Conclusions: Elevated hsCRP may reflect increased cardiovascular risk in children with NB. While adiponectin levels were also altered, their association with cardiovascular risk appears more complex and may involve additional metabolic mechanisms.
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