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RNA Polymerase III-Transcribed RNAs in Health and Disease: Mechanisms, Dysfunction, and Future Directions

Longjie Sun1, Mingyue Chen2, Xin Wang1

  • 1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

International Journal of Molecular Sciences
|June 26, 2025
PubMed
Summary

RNA polymerase III (Pol III) transcribes essential non-coding RNAs involved in cellular functions. Dysfunctional Pol III transcripts are linked to diseases, highlighting their therapeutic potential.

Keywords:
RNA polymerase IIIdiseasenon-coding RNAstranscriptometsRNAs

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