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Oral Findings Linked to Chronic Kidney Disease: A Comprehensive Systematic Review
Paula García-Rios1, Francisco Javier Rodríguez-Lozano1, Nuria Pérez-Guzmán1
1Gerodontologý an Special Care Dentistry Unit, Morales Meseguer Hospital, Faculty of Medicine, IMIB-Arrixaca, University of Murcia, 30008 Murcia, Spain.
Journal of Clinical Medicine
|June 26, 2025
Summary
Chronic kidney disease (CKD) is linked to oral health issues like hyposalivation and periodontal disease. Early detection and multidisciplinary care are crucial for managing these oral manifestations in CKD patients.
Area of Science:
- Nephrology
- Oral Medicine
- Systematic Review
Background:
- Chronic kidney disease (CKD) is irreversible, often asymptomatic initially.
- Oral manifestations like hyposalivation and enamel defects are common in CKD patients.
- These oral symptoms impact diagnosis and quality of life.
Purpose of the Study:
- To systematically review oral manifestations in CKD patients.
- To assess the relevance of these oral symptoms.
- To identify correlations between oral symptoms and CKD clinical parameters.
Main Methods:
- Systematic review following PRISMA guidelines.
- Searched PubMed, Scopus, Scielo, Cochrane Library.
- Included observational studies from the last ten years; assessed quality using NOS and JBI checklists.
Main Results:
- 27 studies included, mostly cross-sectional.
- Common oral issues: hyposalivation, calculus/plaque, enamel defects, periodontal disease, candidiasis.
- Linked dialysis duration to periodontal disease severity and CKD stage to taste dysfunction.
Conclusions:
- CKD is clearly associated with oral health disturbances.
- Further research needed on oral-systemic interactions in CKD.
- Multidisciplinary care approaches are essential.
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