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Updated: Sep 18, 2025

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Interstitial Cystitis/Bladder Pain Syndrome Patient Phenotyping.

Dylan T Wolff1, Stephen Tranchina1, Andrew Schrepf2

  • 1Department of Urology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Neurourology and Urodynamics
|June 26, 2025
PubMed
Summary
This summary is machine-generated.

Interstitial cystitis/bladder pain syndrome (IC/BPS) patient phenotypes can be categorized as bladder-centric or systemic. Understanding these distinct groups is crucial for targeted treatment development and improved outcomes in IC/BPS management.

Keywords:
consensusinterstitial cystitis/bladder pain syndromephenotyping

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Area of Science:

  • Urology
  • Pain Medicine
  • Regenerative Medicine

Background:

  • Interstitial cystitis/bladder pain syndrome (IC/BPS) is a complex condition with varied patient presentations.
  • Current understanding necessitates refined diagnostic and treatment strategies.

Purpose of the Study:

  • To establish global consensus on patient phenotyping in IC/BPS.
  • To review evidence supporting different IC/BPS phenotypic groups.

Main Methods:

  • A narrative review of published evidence was conducted.
  • Focused on patient phenotyping within the context of a Global Consensus meeting.

Main Results:

  • Patients with IC/BPS can be broadly classified into bladder-centric, systemic, or other phenotypes (e.g., myofascial pelvic pain).
  • Evidence supports the existence and clinical relevance of these distinct phenotypic groups.

Conclusions:

  • Future IC/BPS clinical trials must incorporate patient phenotyping, stratifying into bladder-centric and systemic groups.
  • Refining discriminative thresholds and understanding phenotype-treatment interactions are vital for advancing IC/BPS research and care.