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Updated: Sep 18, 2025
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
White Matter Hyperintensity Multispot Pattern Lesions and Cerebrovascular Amyloid Burden in Cerebral Amyloid
Andreas Charidimou1, Jean-Claude Baron2
1Department of Neurology, Boston University Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (A.C.).
Background:
We investigated the relationship between white matter hyperintensity (WMH) multispot pattern lesions, a supporting magnetic resonance imaging marker of cerebral amyloid angiopathy (CAA), and positron emission tomography-based amyloid-β burden across a range of cerebrovascular amyloid deposition.
Methods:
Twenty-one nondemented subjects (11 patients with probable CAA; median age, 71 [63-77] years; 82% males; and 10 healthy subjects; median age, 63.5 [61-68] years; 50% males) underwent brain magnetic resonance imaging and 11C-Pittsburgh compound B-positron emission tomography imaging. WMH multispot lesions were evaluated on fluid-attenuated inversion recovery sequences. The association between whole cortex 11C-Pittsburgh compound B binding and WMH multispot lesions count was assessed using Kendall tau, adjusting for key markers of CAA through a hierarchical residualization approach.
Results:
The unadjusted analysis showed a positive correlation between WMH multispot lesions count and whole cortex 11C-Pittsburgh compound B binding (tau-b=0.495; P=0.0017). Sequential adjustments for the presence of severe magnetic resonance imaging-visible perivascular spaces in the centrum semiovale, lobar cerebral microbleeds, age, and total WMH burden led to a progressive decline in correlation. The largest reduction occurred after adjusting for age (tau-b=0.307; P=0.0484) indicating its role as a potential confounder. In the fully adjusted model, the association remained significant (tau-b=0.316; P=0.0423), suggesting a partially independent relationship between WMH multispot lesions count and whole cortex amyloid burden. The results were consistent in a subanalysis within the probable CAA.
Conclusions:
This pilot study suggests a positive association between cerebrovascular amyloid deposition and WMH multispot lesions in CAA, with potential pathophysiological and clinical implications. These exploratory observations require confirmation in larger studies.
