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Updated: Sep 18, 2025

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Generation and Use of Reactive Intermediates Exploiting Flow Technology.

Philip Jamieson1, Davin Cronly2, Marcus Baumann3

  • 1School of Chemistry, University College Dublin, Dublin. philip.jamieson@ucdconnect.ie.

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|June 26, 2025
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Continuous flow technology enables safe, on-demand generation of reactive intermediates. This review highlights recent advances in photochemistry, metalation, and electrochemistry for streamlined chemical synthesis.

Keywords:
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Area of Science:

  • Chemistry
  • Chemical Engineering
  • Organic Synthesis

Background:

  • Continuous flow technology is a mature and widely adopted technique in academic and industrial settings.
  • Miniaturized flow systems offer enhanced safety and on-demand production of reactive intermediates.
  • Streamlined synthesis routes are crucial for producing valuable chemical building blocks efficiently.

Purpose of the Study:

  • To provide an updated review of recent studies utilizing continuous flow technology.
  • To highlight the application of photochemistry, metalation, and electrochemistry in flow systems.
  • To showcase successful implementations and identify future opportunities in flow processing for reactive intermediate generation.

Main Methods:

  • Review of recent scientific literature on continuous flow chemistry.
  • Focus on studies employing photochemistry, metalation reactions, and electrochemistry.
  • Analysis of the generation of reactive intermediates in flow reactors.

Main Results:

  • Demonstration of successful applications of continuous flow for generating diverse reactive intermediates.
  • Identification of specific advancements in photochemical, metalation, and electrochemical flow processes.
  • Highlighting the benefits of flow technology for safer and more efficient chemical synthesis.

Conclusions:

  • Continuous flow technology is a powerful tool for the on-demand generation of reactive intermediates.
  • Photochemistry, metalation, and electrochemistry are key enabling techniques within flow chemistry.
  • Further opportunities exist for optimizing and expanding the use of flow processing in chemical synthesis.