Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

348
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
348
Modeling in Therapy01:26

Modeling in Therapy

153
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
153

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic resonance spectroscopy during migraine attacks: A systematic review.

Cephalalgia : an international journal of headache·2026
Same author

Mortality in Autism: A Longitudinal Register-Based Study.

Journal of autism and developmental disorders·2026
Same author

Visualizations during arithmetic tasks hamper performance and increase cognitive load in 9-year-olds: an fNIRS study.

Frontiers in psychology·2026
Same author

Is the Kent-Rosanoff Word Association Task Helpful in Characterizing Language Difficulties in 6- to 9-Year-Old Children with Autism?

Autism & developmental language impairments·2026
Same author

Trade-off between speed and accuracy: associations between obsessive-compulsive symptoms and meticulousness in PANS.

Journal of clinical and experimental neuropsychology·2026
Same author

Intensive Multidisciplinary Intervention for Young Children With ARFID: Clinical Outcomes and Parental Experiences From a Prospective Cohort Study.

The International journal of eating disorders·2026
Same journal

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same journal

Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population-Based Study From Southern Finland.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same journal

Re: Comment on "Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4-6 Years With Obesity".

Acta paediatrica (Oslo, Norway : 1992)·2026
Same journal

Impact of Phototherapy Blanket Treatment on Need for Overhead Phototherapy in Term Infants-A Randomised Controlled Trial (The Babies in Blankets Trial-BiB Trial).

Acta paediatrica (Oslo, Norway : 1992)·2026
Same journal

Comment on 'Metabolic Risk Factors Are Associated With Weight Status Change Over 4 Years in Children Aged 4-6 Years With Obesity'.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same journal

Low Serum Alkaline Phosphatase Levels in Paediatric sepsis Correlate With Acute Kidney Injury: A Multicenter Retrospective Study.

Acta paediatrica (Oslo, Norway : 1992)·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
06:15

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Published on: October 3, 2018

7.8K

Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist-Control Study.

Elisabeth Fernell1,2, Sara Landberg1, Carmela Miniscalco1

  • 1Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|June 26, 2025
PubMed
Summary
This summary is machine-generated.

Bumetanide treatment showed potential benefits for some children with autism, with 4 out of 9 participants experiencing significant improvements. This diuretic influences neuronal chloride homeostasis, potentially aiding autism symptom management.

Keywords:
autismbumetanidechildrentreatment study

More Related Videos

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.7K
A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

11.7K

Related Experiment Videos

Last Updated: Sep 18, 2025

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
06:15

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Published on: October 3, 2018

7.8K
Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.7K
A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

11.7K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Developmental Pediatrics

Background:

  • Bumetanide, a diuretic, modulates neuronal chloride homeostasis.
  • This mechanism may restore GABAergic inhibition and balance neuronal signaling.
  • Preclinical and prior clinical research suggests potential benefits for autism spectrum disorder (ASD).

Purpose of the Study:

  • To evaluate the efficacy of bumetanide in children with autism.
  • To build upon existing preclinical and clinical findings regarding bumetanide for ASD.
  • To assess the impact of bumetanide on autism-related symptoms and behaviors.

Main Methods:

  • A 9-month randomized waitlist-control study involving 15 children (aged 4-12) diagnosed with autism.
  • Participants were randomized to immediate bumetanide treatment or a 3-month delayed start.
  • Parent-completed rating scales assessed symptoms, behaviors, and functioning at multiple time points.

Main Results:

  • Two children were excluded early due to behavioral issues.
  • Four of the 13 participants who started bumetanide discontinued treatment between 4-6 months.
  • Four of the 9 children who completed the 9-month study showed significant clinical improvements, opting for continued treatment.

Conclusions:

  • This small study suggests bumetanide may offer benefits for a subset of children with autism.
  • Further research is warranted to confirm these findings in larger cohorts.
  • Bumetanide's potential role in managing autism symptoms warrants continued investigation.