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Oligodendroglioma: incidence and biological behavior in a defined population
Journal of Neurosurgery
|December 1, 1985
Summary
Oligodendrogliomas, a type of primary brain tumor, show a poorer prognosis than previously thought. Tumor calcification and complete surgical removal significantly improve survival rates for these patients.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Epidemiology
Background:
- Oligodendrogliomas represent 4.2% of primary brain tumors in Norway.
- These tumors predominantly affect the frontal lobe, with a median patient age of 47 years.
Purpose of the Study:
- To analyze the incidence, clinical characteristics, and prognostic factors of oligodendrogliomas.
- To evaluate survival rates and identify predictors of outcome in a large patient cohort.
Main Methods:
- Retrospective analysis of 208 histologically confirmed oligodendroglioma cases over 25 years.
- Correlation of clinical data, surgical findings, and radiographic features with patient survival.
Main Results:
- Median survival from symptom onset was 74 months for surgically treated patients, with 5-year survival at 34.2%.
- Tumor calcification, gross total resection, and favorable preoperative status were associated with longer survival.
- Blood group A indicated a poorer prognosis.
Conclusions:
- Cerebral oligodendrogliomas have a less favorable prognosis than commonly believed.
- Tumor calcification and extent of surgical resection are significant prognostic indicators.
- Patient age and sex did not significantly impact survival, but ABO blood group did.