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Detecting Deleterious Recessive Variants in Large Yellow Croaker Using Data from 7337 Individuals
Zhou Jiang1,2, Ji Zhao1,2,3, Ning Li1,2
1Fujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen, 361102, China.
Marine Biotechnology (New York, N.Y.)
|June 26, 2025
Summary
Researchers identified 22 genetic loci lacking recessive homozygous genotypes in large yellow croaker (Larimichthys crocea). This finding aids selective breeding to reduce lethal mutations and improve aquaculture sustainability.
Area of Science:
- Aquaculture Genetics
- Population Genomics
- Marine Biology
Background:
- Deleterious recessive alleles in homozygous states cause lethal effects in diploid organisms.
- Large yellow croaker (Larimichthys crocea) exhibits inbreeding depression due to limited natural distribution and intensive aquaculture.
- Identifying loci with missing recessive homozygous genotypes is vital for sustainable aquaculture.
Purpose of the Study:
- To identify loci with missing recessive homozygous genotypes in large yellow croaker.
- To provide insights for selective breeding programs to enhance population fitness.
- To support the sustainable development of the large yellow croaker aquaculture industry.
Main Methods:
- Genotype analysis of 1844 large yellow croaker across three generations.
- Parentage analysis to exclude false positives and large-scale validation on 7337 individuals.
- Loci annotation and linkage disequilibrium analysis, followed by experimental verification.
Main Results:
- 22 loci with a complete absence of recessive homozygous genotypes were identified across 7337 individuals.
- 12 associated genes involved in crucial biological processes were annotated.
- Experimental verification confirmed the absence of recessive homozygous genotypes in offspring from selected heterozygous crosses.
Conclusions:
- The study successfully identified key genetic loci with missing recessive homozygous genotypes in large yellow croaker.
- These findings offer valuable guidance for selective breeding strategies to minimize lethal mutations.
- The research contributes to enhancing population fitness and promoting sustainable aquaculture development.
