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Brewing a Cure: Engineering Yeast to Reduce Inflammation-Driven Tumors
1Division of Biomedical Sciences, School of Medicine, University of California, Riverside, 900 University Avenue, Riverside, CA, 92115, USA. declan.mccole@ucr.edu.
Digestive Diseases and Sciences
|June 26, 2025
Abstract:
Culpepper et al. developed a novel bioengineered yeast-Saccharomyces boulardii-designed to specifically target exposed fibronectin in inflamed intestinal tissues and release anti-TNF nanobodies with the goal of reducing inflammation-driven tumorigenesis in a mouse model of colorectal adenocarcinoma.
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