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Updated: Sep 18, 2025

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Carbapenem-resistant Providencia spp.: the threat at the door

Onur Ozalp1, Baran Ortakci1, Selda Komec2

  • 1Department of Infectious Diseases and Clinical Microbiology, Basaksehir Cam and Sakura Hospital, University of Health Sciences, Istanbul, Turkey.

The Journal of Hospital Infection
|June 26, 2025
PubMed
Abstract

Insights

Carbapenem-resistant Providencia infections, often caused by P. rettgeri, lead to worse outcomes and higher mortality. Strengthening infection control and antimicrobial stewardship is crucial for managing these challenging nosocomial infections.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Providencia species are increasingly recognized as opportunistic nosocomial pathogens.
  • Carbapenem-resistant Providencia spp. present a significant therapeutic challenge due to limited treatment options.

Purpose of the Study:

  • To evaluate clinical characteristics, risk factors, and outcomes of carbapenem-resistant versus carbapenem-susceptible Providencia spp. infections.
  • To identify independent risk factors associated with carbapenem resistance in Providencia isolates.

Main Methods:

  • Retrospective observational study of hospitalized patients with Providencia spp. isolates (2020-2024).
  • Stratification of patients based on carbapenem susceptibility.
  • Comparison of clinical data, risk factors, and mortality rates between resistant and susceptible groups.

Main Results:

  • 44.9% of 118 Providencia infections were carbapenem-resistant, predominantly P. rettgeri.
  • Carbapenem-resistant infections were linked to longer hospital stays, ICU admissions, and higher mortality.
  • Risk factors for resistance included prior ICU admission, mechanical ventilation, urinary catheterization, and prior carbapenem use.

Conclusions:

  • Carbapenem-resistant Providencia infections are associated with increased morbidity and mortality.
  • Enhanced infection control and antimicrobial stewardship are essential.
  • Further research is needed on resistance mechanisms and optimal treatment strategies.
Keywords:
Antimicrobial resistanceCarbapenem resistanceMortalityNosocomial infectionsProvidencia spp.

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