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Contribution of MRE11, RAD50, and NBS1 Genotypes to Bladder Cancer Susceptibility

Cheng-Hsi Liao1,2, Wen-Shin Chang3,4, Hou-Yu Shih3,4

  • 1Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.

Cancer Genomics & Proteomics
|June 26, 2025
PubMed
Abstract

Insights

The NBS1 rs2735383 genotype is linked to increased bladder cancer risk, especially in older adults, smokers, and drinkers. This finding suggests NBS1 genotype as a potential biomarker for bladder cancer susceptibility.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Genome instability accelerates cancer development, often due to DNA damage response defects.
  • The MRE11-RAD50-NBS1 (MRN) complex is vital for DNA damage sensing and repair.
  • Limited research exists on MRN genotypes and bladder cancer (BLCA) susceptibility.

Purpose of the Study:

  • To investigate the association between MRN gene polymorphisms and BLCA risk.
  • To identify specific MRN genotypes that may influence susceptibility to bladder cancer.

Main Methods:

  • Genotyping of 14 single nucleotide polymorphisms (SNPs) within the MRE11, RAD50, and NBS1 genes.
  • Analysis of 375 BLCA cases and 375 controls to evaluate SNP contributions to BLCA susceptibility.

Main Results:

  • The NBS1 rs2735383 polymorphism was significantly associated with increased BLCA risk (p=0.0053).
  • Both CG and CC genotypes of NBS1 rs2735383 conferred higher risks (OR=1.48 and 1.95, respectively).
  • Subgroup analyses revealed NBS1 rs2735383 is linked to higher risk in individuals over 55, smokers, alcohol drinkers, and those with muscle-invasive disease.

Conclusions:

  • The NBS1 rs2735383 genotype may serve as a genetic biomarker for BLCA susceptibility.
  • This biomarker is particularly relevant in high-risk subpopulations like elders, smokers, drinkers, and patients with muscle-invasive disease.
Keywords:
Bladder CancerTaiwandouble strand breaksgenotypepolymorphism

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