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Cobalt(II) Complexes of 4'-Nitro-Fenamic Acid: Characterization and Biological Evaluation
Georgios Malis1, Antigoni Roussa1, Efstathia Aikaterini Papantopoulou2
1Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Molecules (Basel, Switzerland)
|June 27, 2025
Summary
This study synthesized novel cobalt(II) complexes with a nitro-fenamic acid ligand. These complexes show significant antioxidant and antimicrobial activities, interact with DNA, and exhibit enhanced DNA cleavage under light, indicating potential as photodynamic therapeutic agents.
Area of Science:
- Coordination Chemistry
- Bioinorganic Chemistry
- Medicinal Chemistry
Background:
- Fenamic acid derivatives are explored for biological applications.
- Cobalt(II) complexes offer diverse coordination possibilities and potential therapeutic uses.
- Nitro-functionalization can modulate ligand properties and complex activity.
Purpose of the Study:
- Synthesize and characterize novel cobalt(II) complexes using a nitro-fenamic acid ligand.
- Evaluate the synthesized complexes for antioxidant, antimicrobial, DNA binding, DNA cleavage, and albumin binding activities.
- Investigate the potential of these complexes as photodynamic therapeutic agents.
Main Methods:
- Synthesis of 4'-nitro-fenamic acid and its cobalt(II) complexes.
- Characterization using elemental analysis, spectroscopy (IR, UV-vis), conductivity, and X-ray crystallography.
- Biological assays including antioxidant, antimicrobial, DNA interaction, DNA cleavage, and serum albumin binding studies.
Main Results:
- Four novel cobalt(II) complexes were successfully synthesized and characterized.
- The complexes demonstrated significant antioxidant activity against H2O2 and free radicals.
- Antimicrobial activity was observed against tested bacterial strains, with notable DNA intercalation and photo-enhanced DNA cleavage.
- Strong binding affinity to both bovine and human serum albumins was confirmed.
Conclusions:
- The synthesized cobalt(II) complexes possess promising antioxidant, antimicrobial, and DNA-interacting properties.
- The photo-enhanced DNA cleavage ability highlights their potential as photodynamic therapeutic agents.
- Reversible binding to serum albumins suggests favorable pharmacokinetic profiles.
Keywords:
affinity for albuminsantibacterial activityantioxidant activitycobalt(II) complexesfenamatesinteraction with DNAtransition metal complexesMore Related Videos
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