Application of Pure and Ion-Doped FeB, CoB, MnB, and Fe2B Nanoparticles for Magnetic Hyperthermia

This study investigates Mn_1-xX_xB (X = Fe, Co) and (Fe_1-xCo_x)₂B nanoparticles as candidates for self-controlled magnetic hyperthermia (SCMH) in cancer therapy. Using a microscopic model and Green's function techniques, we calculate the Curie temperature, saturation magnetization, coercivity, and specific absorption rate as functions of nanoparticle size and dopant concentration. Surface and size effects are taken into account. The results are in good agreement with experimental data, confirming the model's validity and highlighting the potential of these nanoparticles for efficient and safe magnetic hyperthermia applications. We have found that pure and doped MnB and Co₂B nanoparticles with specific compositions meet biocompatibility requirements for SCMH suitable for in vivo and in vitro, for example, Mn_0.6Co_0.4B (d = 27.1 nm); Mn_0.5Co_0.5B (d = 32.2 nm); MnB (d = 26.3 m); (Fe_0.2Co_0.8)₂B (d = 22.0 nm); (Fe_0.1Co_0.9)₂B (d = 26.3 nm); and Co₂B (d = 31.7 nm).