Analysis of the Correlation Between MDS Inflammatory Indicators and Clinical Characteristics: A Comprehensive...

Area of Science:

• Hematology
• Oncology
• Immunology

Background:

• Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
• Inflammation plays a crucial role in MDS pathogenesis and progression.
• Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are emerging inflammatory markers.

Purpose of the Study:

• To investigate the correlations between NLR, MLR, and PLR with clinical characteristics in newly diagnosed MDS patients.
• To explore the diagnostic and prognostic value of these inflammatory markers in MDS.
• To provide a basis for early assessment of treatment efficacy and personalized treatment strategies.

Main Methods:

• Analysis of bone marrow smears and flow cytometry immunophenotyping in 70 MDS patients.
• Comparative analysis of multi-parameter linear correlation between clinical characteristics and inflammatory markers.
• Differential correlation analysis based on MDS subtypes, immunophenotypic characteristics, and morphological features.

Main Results:

• NLR and PLR demonstrated good diagnostic specificity for MDS (AUC=0.9169, 0.8312).
• MLR correlated with white blood cell count (r=0.661, p=0.0004), and NLR with LDH (r=0.313, p=0.037).
• Significant differences in inflammatory markers were observed across different MDS WHO classifications and immunophenotypic groups. CD34 proportion negatively correlated with NLR (r=-0.296, p=0.0129), and lower PLR predicted longer survival.

Conclusions:

• Inflammatory markers (NLR, MLR, PLR) are significantly correlated with clinical characteristics and tumor burden in MDS.
• These markers offer auxiliary diagnostic evidence and reflect differences based on disease status.
• The findings suggest these markers can guide treatment strategies to inhibit MDS progression to acute leukemia by modulating the inflammatory trend.