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Related Experiment Video

Updated: Sep 17, 2025

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Association Between a Decrease in Blood Monocyte Counts and Necrotizing Enterocolitis in Preterm Infants.

Supriya Bisht¹, Kim Roger², Sharef Al-Mulaabed³

¹Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, USA.

|June 27, 2025

Summary

This summary is machine-generated.

A decrease in absolute monocyte count (AMC) was linked to necrotizing enterocolitis (NEC) in preterm infants. A falling AMC may serve as an early biomarker for increased NEC risk in neonates with feeding issues.

Keywords:

absolute monocyte count feeding intolerance necrotizing enterocolitis neonate preterm

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Area of Science:

Neonatal Medicine
Hematology
Pediatric Surgery

Background:

Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition affecting preterm infants.
Early identification of NEC risk is crucial for timely intervention and improved outcomes.
Absolute monocyte count (AMC) is a component of the complete blood count (CBC).

Purpose of the Study:

To investigate the relationship between AMC and NEC in preterm neonates.
To determine if a decline in AMC can predict an elevated risk of NEC.

Main Methods:

Retrospective analysis of preterm neonates diagnosed with NEC or feeding intolerance (FI).
Evaluation of AMC from complete blood counts at baseline, onset of NEC/FI, and post-event.
Statistical comparison using Student's t-test and chi-squared test.

Main Results:

A significant increase in AMC was observed from baseline to onset in the feeding intolerance group (p<0.001).
The NEC group showed a non-significant trend of falling AMC from baseline to onset (p=0.074).
Of 92 neonates, 29 had NEC and 63 had FI; groups were comparable in gestational age and birth weight.

Conclusions:

A decrease in AMC is associated with the presence of NEC in preterm infants.
A falling AMC may function as a predictive biomarker for NEC risk in neonates experiencing feeding problems.