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Related Experiment Video

Updated: Sep 17, 2025

Microarray Analysis for Saccharomyces cerevisiae
13:17

Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

13.8K

Becoming fully circular facilitated by PAT.

Tobias Eifert1,2, Martin Gerlach2,3, Katharina Dahlmann2,4

  • 1, Covestro, Uerdingen, Krefeld, Germany.

Analytical and Bioanalytical Chemistry
|June 27, 2025
PubMed
Summary

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This summary is machine-generated.

Process analytical technologies (PAT) enhance industrial efficiency and sustainability through real-time monitoring. This review highlights PAT applications in recycling, biotech, and pharmaceutical production, showcasing its vital role in modern quality by design.

Area of Science:

  • Chemical Engineering
  • Analytical Chemistry
  • Process Control

Background:

  • Process Analytical Technologies (PAT) have driven industrial process improvements for over 20 years.
  • Real-time monitoring is crucial for process control, knowledge acquisition, and Quality by Design (QbD).
  • Advancements in instrumentation and data analysis solidify PAT's role in QbD.

Purpose of the Study:

  • To celebrate the 20th anniversary of Arbeitskreis PAT of the GDCh.
  • To present diverse use cases of PAT in current and future industrial processes.
  • To provide a perspective on future PAT developments.

Main Methods:

  • Review of five distinct PAT application examples.
  • Utilization of techniques including online solid-phase extraction, ion-chromatography, NIR/mid-IR spectroscopy, and VCD.
Keywords:
Infrared spectroscopyProcess analytical technologyQuantum cascade laser vibrational circular dichroismSingle-use technologySolid-phase extraction ion-chromatography conductivity

Related Experiment Videos

Last Updated: Sep 17, 2025

Microarray Analysis for Saccharomyces cerevisiae
13:17

Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

13.8K
  • Focus on monitoring sustainable processes and product safety.

    • Main Results:

    • Demonstrated PAT's impact on sustainable process monitoring (water, solvent, plastic recycling).
    • Showcased PAT in biotechnological production with single-use technology.
    • Illustrated PAT for pharmaceutical product safety and real-time release testing.

    Conclusions:

    • PAT is integral to achieving efficient, sustainable, and reliable industrial operations.
    • The presented methodologies highlight the versatility and power of PAT.
    • Future developments in PAT promise further advancements in process understanding and control.