Becoming fully circular facilitated by PAT

Area of Science:

• Chemical Engineering
• Analytical Chemistry
• Process Control

Background:

• Process Analytical Technologies (PAT) have driven industrial process improvements for over 20 years.
• Real-time monitoring is crucial for process control, knowledge acquisition, and Quality by Design (QbD).
• Advancements in instrumentation and data analysis solidify PAT's role in QbD.

Purpose of the Study:

• To celebrate the 20th anniversary of Arbeitskreis PAT of the GDCh.
• To present diverse use cases of PAT in current and future industrial processes.
• To provide a perspective on future PAT developments.

Main Methods:

• Review of five distinct PAT application examples.
• Utilization of techniques including online solid-phase extraction, ion-chromatography, NIR/mid-IR spectroscopy, and VCD.
• Focus on monitoring sustainable processes and product safety.

Main Results:

• Demonstrated PAT's impact on sustainable process monitoring (water, solvent, plastic recycling).
• Showcased PAT in biotechnological production with single-use technology.
• Illustrated PAT for pharmaceutical product safety and real-time release testing.

Conclusions:

• PAT is integral to achieving efficient, sustainable, and reliable industrial operations.
• The presented methodologies highlight the versatility and power of PAT.
• Future developments in PAT promise further advancements in process understanding and control.