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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian clock and its effect on aging and lifespan
Avnish Kumar Verma1, Sandeep Singh1, Syed Ibrahim Rizvi2
1Department of Biochemistry, University of Allahabad, Allahabad, 211002, India.
Biogerontology
|June 27, 2025
Summary
Aging disrupts cellular circadian rhythms, impacting health and longevity. Lifestyle interventions like diet and exercise can reset these rhythms, promoting healthy aging and extending lifespan.
Area of Science:
- Chronobiology
- Gerontology
- Molecular Biology
Background:
- Cellular circadian clocks regulate daily rhythms essential for homeostasis and resilience.
- Aging impairs circadian system synchrony, exacerbating age-related disorders.
- Modern lifestyles contribute to circadian disruption, negatively affecting aging and longevity.
Purpose of the Study:
- To review the impact of aging on circadian function.
- To examine the reciprocal effects of circadian disruption on aging and longevity.
- To highlight non-pharmacological interventions for circadian regulation and healthy aging.
Main Methods:
- Literature review of aging and circadian rhythm research.
- Analysis of studies on lifestyle factors influencing circadian function.
- Examination of animal model data on circadian disruption and lifespan.
Main Results:
- Aging negatively affects circadian rhythmicity and synchrony.
- Circadian disruption accelerates aging processes and reduces lifespan in models.
- Dietary restrictions and physical exercise show potential for regulating circadian rhythms and promoting longevity.
Conclusions:
- Resetting the circadian clock is crucial for maintaining cellular homeostasis and physiology.
- Interventions targeting circadian rhythms offer therapeutic potential for healthy aging.
- Non-pharmacological approaches can mitigate negative effects of circadian disruption on aging and lifespan.
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