Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maintenance Inhaled Corticosteroid Use is Associated With Increased Revision Risk in Asthmatic Patients Undergoing Lumbar Fusion.

Global spine journal·2026
Same author

Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.

Critical care (London, England)·2026
Same author

Comparison of analgesic efficacy of ropivacaine versus ropivacaine plus dexmedetomidine in modified thoracolumbar interfascial plane block in patients undergoing lumbar disc surgeries: A randomised controlled trial.

Indian journal of anaesthesia·2026
Same author

Osteochondral Allograft Reconstruction for Post-traumatic Osteo-Articular Defects of the Knee: A Case Report.

JBJS case connector·2026
Same author

Effectiveness of high-frequency repetitive transcranial magnetic stimulation coupled with rehabilitation in patients with spinal cord injury: a systematic review.

Neurological research·2025
Same author

Effect of perioperative transdermal nicotine patch on postoperative pain: A systematic review and meta-analysis.

Indian journal of anaesthesia·2025

Related Experiment Video

Updated: Sep 8, 2025

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.9K

Corticospinal Intermittent Theta Burst Stimulation Propelling Sensorimotor Function Recovery in Complete Spinal Cord

Deeksha Patel1, Rohit Banerjee1, Kamran Farooque2

  • 1Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

JMIR Research Protocols
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

Intermittent theta burst stimulation (iTBS) may improve motor and sensory function in patients with complete spinal cord injury (cSCI). This noninvasive technique enhances neural plasticity, potentially aiding recovery and quality of life.

Keywords:
American Spinal Injury Association Impairment Scaleexcitatory-inhibitory circuitryintermittent theta burst stimulationphysical rehabilitationprotocolrandomized control trialspinal cord injurysynaptic plasticity

More Related Videos

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.3K
TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
10:58

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

17.1K

Related Experiment Videos

Last Updated: Sep 8, 2025

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
14:47

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

Published on: April 21, 2023

2.9K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.3K
TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism
10:58

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

17.1K

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Intermittent theta burst stimulation (iTBS) is a noninvasive neuromodulation technique that induces neuronal and synaptic plasticity, crucial for sensorimotor function recovery.
  • Spinal cord injury (SCI) impairs neuronal function, leading to sensorimotor deficits. The efficacy of iTBS in promoting recovery in complete SCI (cSCI) remains under investigation.
  • This study investigates iTBS's potential to enhance corticospinal tract integrity and plasticity for motor and sensory function recovery in cSCI patients.

Purpose of the Study:

  • To assess the impact of iTBS on corticospinal tract integrity and plasticity in patients with cSCI.
  • To evaluate the effectiveness of iTBS in restoring motor and sensory function following cSCI.
  • To explore iTBS's role in augmenting neural communication and synaptic transmission for improved motor control in cSCI.

Main Methods:

  • Forty patients with cSCI (ASIA grade A, aged 18-60) were randomized into placebo, repetitive TMS, and iTBS groups, with further subdivisions for stimulation site (motor cortex, spinal cord, combined).
  • Each patient received 10 iTBS sessions twice daily for 5 consecutive days.
  • Assessments included neurological and functional outcomes, electrophysiological evaluations (TMS single- and paired-pulse), biomarkers (ELISA), and neurotransmitters (LC-MS), with pre-intervention, post-intervention, and 1, 2, 3-month follow-ups.

Main Results:

  • Outcomes measured include electrophysiological parameters, ASIA scores, pain levels, daily living activities, quality of life, anxiety, depression, and SCI-related biomarkers.
  • The study aims to determine iTBS's effectiveness in motor and sensory function recovery, corticospinal tract excitability, neurological recovery, pain modulation, and cortical reorganization post-injury.

Conclusions:

  • iTBS, combined with tailored rehabilitation, shows promise as an integrated strategy to improve locomotor function in individuals with cSCI.
  • This approach may significantly enhance the overall quality of life for patients recovering from cSCI.