Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

193
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
193
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Bone Disorders01:29

Bone Disorders

4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Mitochondria01:37

Mitochondria

15.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.1K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.6K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypergravity and ERK Inhibition Combined Synergistically Reduce Pathological Tau Phosphorylation in a Neurodegenerative Cell Model.

Cells·2025
Same author

Wolffia globosa, a novel crop species for protein production in space agriculture.

Scientific reports·2024
Same author

Growth and mineralization of fetal mouse long bones under microgravity and daily 1 g gravity exposure.

NPJ microgravity·2024
Same author

How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

NPJ microgravity·2024
Same author

How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

NPJ microgravity·2024
Same author

How do gravity alterations affect animal and human systems at a cellular/tissue level?

NPJ microgravity·2023
Same journal

Sinomenine Regulates the TRIM32/IRF1/TRAF6 Axis to Inhibit Pyroptosis in Atopic Dermatitis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Urolithin A Mitigates Renal Fibrosis by Promoting Fatty Acid Oxidation Through Orchestrating β-Catenin Signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

MiR-124 Inhibits Lipid Deposition in Mouse Liver by Targeting the Trib3/Hnf4α Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

TCN2 Drives Psoriasis-Like Inflammation and Keratinocyte Hyperproliferation, Correlating With IL-1β and STAT3 Activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Brain-Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Related Experiment Video

Updated: Sep 17, 2025

Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.1K

Aging and Altered Gravity: A Cellular Perspective.

Sharon van Rijthoven1,2, Jack J W A van Loon2,3

  • 1Delft University of Technology, Delft, the Netherlands.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

Cellular aging and spaceflight share surprising similarities, but only 29% of aging signs are replicated in microgravity. Mechanotransduction may explain these shared phenotypes, suggesting new research avenues for age-related and space-induced health challenges.

Keywords:
agingaltered gravityhypergravitymicrogravitysenescence

More Related Videos

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.0K
Automated Analysis of C. elegans Swim Behavior Using CeleST Software
08:47

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Published on: December 7, 2016

12.9K

Related Experiment Videos

Last Updated: Sep 17, 2025

Propagation of Dental and Respiratory Cells and Organs in Microgravity
06:29

Propagation of Dental and Respiratory Cells and Organs in Microgravity

Published on: May 25, 2021

2.1K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.0K
Automated Analysis of C. elegans Swim Behavior Using CeleST Software
08:47

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Published on: December 7, 2016

12.9K

Area of Science:

  • Cellular biology
  • Gerontology
  • Space medicine

Background:

  • The elderly and astronauts display similar physiological changes.
  • Previous research focused on organism/organ levels, leaving cellular comparisons limited.
  • Understanding cellular aging and gravity's effects is crucial for health.

Purpose of the Study:

  • To conduct a scoping review comparing cellular aging signs with those in altered gravity.
  • To identify commonalities and differences at the cellular level.
  • To explore mechanotransduction's role in shared phenotypes.

Main Methods:

  • Identified 165 cellular aging signs across 11 themes.
  • Searched Web of Science and PubMed for studies on these signs in altered gravity.
  • Analyzed cellular responses in simulated microgravity versus biological aging.

Main Results:

  • Only 29% of cellular aging signs showed similar responses in microgravity.
  • Other signs exhibited contrasting behavior, indicating complex cellular responses.
  • Most aging signs remain unexplored in altered gravity research.

Conclusions:

  • Cellular aging and microgravity effects are complex and not fully overlapping.
  • Mechanotransduction is a potential key factor in shared phenotypes.
  • Further research on mechanotransduction is recommended for age-related and space-induced health insights.