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Exploring the Emotional Effects of Reproductive Decision-Making in Women With a BRCA Pathogenic Variant
Elizabeth Skrovanek1, Catherine M Bender2, Jacqueline Dunbar-Jacob3
1Elizabeth Skrovanek.
Oncology Nursing Forum
|June 27, 2025
Summary
Women with BRCA pathogenic variants make reproductive decisions influenced by emotional states and individual factors like age and family history. Understanding these factors can improve psychosocial outcomes for hereditary cancer risk.
Area of Science:
- Oncology
- Genetics
- Reproductive Health
Background:
- Women with BRCA pathogenic variants face complex reproductive decisions.
- Hereditary cancer risk significantly impacts life choices.
Purpose of the Study:
- To evaluate how emotional states and individual factors influence reproductive decision-making in women with BRCA pathogenic variants.
- To identify key predictors of reproductive choices in this population.
Main Methods:
- Exploratory, descriptive study of 85 women with BRCA pathogenic variants.
- Appraisal of Life Events Scale used to measure emotional states.
- Binary logistic regression analyzed relationships between emotional states, BRCA status, individual factors, and reproductive decisions.
Main Results:
- Age at genetic testing and number of children predicted decisions on having more children.
- Perceived loss/benefit significantly associated with reproductive decisions in women with a family history of ovarian cancer.
Conclusions:
- Emotional states and individual factors play a crucial role in reproductive decision-making for women with BRCA pathogenic variants.
- Addressing the emotional impact can enhance health and psychosocial outcomes for women at hereditary cancer risk.
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