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Identification of Factors Contributing to Pathogenic Variability Among Lassa Virus Strains Using the Guinea Pig Model

Satoshi Taniguchi1,2, Takeshi Saito1, Ruchi Paroha1

  • 1Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.

The Journal of Infectious Diseases
|June 27, 2025
PubMed
Summary

Researchers identified the L protein of Lassa virus (LASV) as key to disease severity in guinea pigs. This finding helps understand Lassa fever (LF) pathogenesis and develop better diagnostics and treatments.

Keywords:
Lassa virusanimal modelpathogenic mechanismspathogenicityreverse genetics

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