Related Experiment Video
Updated: Aug 10, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Tumor treating fields for glioblastoma: opportunities and drawbacks
Alessandro Pesce1, Mauro Palmieri2, Alessandro Frati2
1Department of Neurosurgery - Policlinico "Tor Vergata", University of Rome ''Tor Vergata", Rome, Italy.
Introduction:
Glioblastoma (GBM) stands as one of the most challenging malignancies to treat, with a prognosis that remains notably poor despite advancements in therapeutic strategies.
Areas Covered:
TTFields therapy is a novel approach to targeting cancer cell proliferation through alternating electric fields. The mechanism of action, dielectrophoresis, selectively disrupts mitotic processes in replicating cells, offering a localized treatment option with minimal systemic side effects.Clinical trials have demonstrated promising results, with TTFields therapy significantly improving progression-free and overall survival rates when combined with standard adjuvant treatments. However, questions regarding its impact on neuropsychological functioning and management of postoperative motor deficits remain unanswered.
Expert Opinion:
In conclusion, while TTFields therapy presents a valuable addition to GBM treatment modalities, further research is warranted to elucidate its full potential and address remaining challenges.
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