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PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential

Chengdong Ji1, Jing Zhu2, Xiaochen Hou2

  • 1Pathology Department, The Ninth People's Hospital of Suzhou, Suzhou, China.

Journal of Cellular and Molecular Medicine
|June 28, 2025
PubMed

Insights

Polypyrimidine tract binding protein 1 (PTBP1) is an RNA-binding protein crucial for gene regulation and tumor progression. This review explores PTBP1

Area of Science:

  • Molecular Biology
  • Cancer Research
  • RNA Biology

Background:

  • Polypyrimidine tract binding protein 1 (PTBP1) is an RNA-binding protein involved in mRNA processing and non-coding RNA functions.
  • PTBP1 plays a significant role in tumorigenesis and cancer progression.
  • PTBP1 is a potential target for cancer therapy.

Purpose of the Study:

  • To review the structure, function, and role of PTBP1 in various tumors.
  • To elucidate the key mechanisms of PTBP1 action in cancer.
  • To discuss challenges and future directions for PTBP1 research and clinical translation.

Main Methods:

  • Literature review of PTBP1 structure and function.
  • Analysis of PTBP1's involvement in different cancer types.
  • Examination of PTBP1's mechanistic roles in tumorigenesis.
  • Discussion of clinical translational potential and future research avenues.

Main Results:

  • PTBP1 regulates mRNA splicing, stability, localization, and translation.
  • PTBP1 influences tumorigenesis and cancer progression through various mechanisms.
  • PTBP1 presents potential as a therapeutic target in oncology.

Conclusions:

  • PTBP1 is a critical regulator in cancer, impacting multiple cellular processes.
  • Understanding PTBP1 mechanisms is vital for developing targeted cancer therapies.
  • Further research into PTBP1 holds promise for advancing precision oncology.
Keywords:
PTBP1RNA modificationalternative splicingtargeted therapytumour translation

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